Preheat your oven to 350°F (175°C) and spray a 9 x 13-inch baking pan with cooking spray.
In a skillet over medium heat, cook the ground beef until no longer pink, breaking it apart for even browning. Drain excess fat.
Add ketchup, water, brown sugar, Worcestershire sauce, mustard, garlic powder, onion powder, and salt to the cooked meat. Stir and let simmer for about five minutes.
Transfer the meat mixture to a bowl, add quartered biscuits, and gently toss until well coated.
Pour the mixture into the prepared baking pan and sprinkle shredded cheddar cheese on top. Bake for about 28-30 minutes or until golden brown.
Let the casserole cool slightly before serving. Cut into squares and enjoy.